AI Career Spotlight: Tom Diethe
/In this career spotlight series, we showcase the career paths, daily work, and impact of people working in AI. Whether you’re an aspiring researcher, an engineer, or simply interested in AI, these stories will give you a firsthand look at the possibilities ahead of you.
Today, we speak with Tom Diethe, Head of the Centre for AI at AstraZeneca. By combining scientific curiosity, technical expertise, and leadership, Tom’s excited to harness AI’s potential to revolutionize healthcare and beyond.
“It’s an amazing area to work in, as we’re on the brink of having agentic AI that can really transform the way we develop drugs to have life changing impacts for our patients.”
Tom’s journey has taken him through diverse sectors like defence and pharma, and settings like Big Tech and academia, to today’s work in an interdisciplinary & collaborative setting.
Tell us a bit about your job
I head up our Centre for AI at AstraZeneca, based in the Biopharma R&D division. We’re a team of AI Scientists and AI Engineers working on a variety of projects across both discovery and development. My own role is a mixture between being a scientist (staying as close as possible to the technical aspects of our projects), a department head, an AI leader within the company, and representing AstraZeneca in the AI community.
Some exciting projects include using AI guided protein for antibodies and other biologics, computer vision applied to many imaging modalities (Echo, Endoscopy, CT, MRI, Retinal …), understanding of mechanisms of action from spatial transcriptomics data, and LLMs for optimising clinical trial documentation. We’re proud to say that we have AI that is designing and screening molecules happening right now, and we’re embedding AI into ways of working across the whole R&D organisation.
It’s an amazing area to work in, as we’re on the brink of having agentic AI that can really transform the way we develop drugs to have life changing impacts for our patients. I’m fortunate to work with amazing specialists in many different areas — medicine, biology, chemistry, regulatory, commercial to name a few — who all come together in a really collaborative setting.
How did you get into the field of AI? What excites you about working in AI?
I was first interested in AI as a teenager after reading “Gödel, Escher, Bach: an Eternal Golden Braid” by Douglas Hofstadter. At that time there wasn’t an obvious route in, so I started by studying Psychology (human intelligence), where I focussed on cognitive science and neuroscience. After graduating I spent a few years in the defence sector working on the “Cognitive Cockpit” project — an early attempt at AI for pilots, the time was right to go back to study again. I first took the MSc in Intelligent Systems at UCL, and after that I was lucky enough to get a place on the PhD programme also at UCL, supervised by the incredible John Shawe-Taylor.
For many years I considered myself as a Machine Learning person, and honestly got a little frustrated by ML being rebranded as AI (what’s an “AI algorithm”!?). However, nowadays I’m really excited by the fact that real AI is now coming to fruition, and I’m starting to feel comfortable calling myself an AI expert! There may be challenges ahead, but the potential of this technology is incredibly exciting, particularly in applications to healthcare.
Can you talk about some of the career choices you’ve made along the way?
In my career I’ve worked in defence, the tech industry, academia, and now pharmaceuticals. One of the toughest choices I had was back in 2014. I was working at Microsoft Research in Cambridge, but ultimately not that happy, and felt that I still needed to enhance my academic profile. I took a research fellowship position at the University of Bristol working in ML applied to digital healthcare (the “SPHERE” project), where I spent 3 amazing years working with Peter Flach and others. It was tough, as it was roughly a 50% pay cut (!!), but thankfully I have an incredibly supportive wife who encouraged me to follow my dreams. Working there really unlocked everything else that came later.
How did you develop the leadership skills you need for your role?
This might be hard to hear, but there aren’t really shortcuts to this! My first jump into (official) management was when I joined Amazon in 2017, and there I developed from a manager of a small number of individuals to eventually leading a larger team (manager of managers), but that’s only part of the picture. For me leadership is about having domain knowledge in your chosen area of expertise, where the challenge then becomes how to keep yourself up to date, particularly in such a fast moving field as AI, combined with learning techniques such as how to coach people rather than simply manage them (“teach a man to fish …”). It’s not something I ever really thought I’d do early in my career since I was really only passionate about the science, but later I realised that I love the people side of my job too, with all the complications it sometimes brings!
What’s your best piece of advice for anyone early on in their AI career?
Don’t be afraid that others seem to know more than you! I spent a lot of energy on conquering my “imposter syndrome”, but at some point you realise everyone else feels the same way!
What are you excited for in the future of AI?
There are many problems in the world at the moment (climate, geopolitics, health crises), and it can feel sometimes like there is only impending doom and no way out. To me AI is humanity’s way out of this — it has the potential to revolutionise everything. Let’s embrace it for the good of people, society and the planet!